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Scientists identify genetic mutation strongly associated with type 1 diabetes
Scientists identify genetic mutation strongly associated with type 1 diabetes

(March 5, 2013 - Insidermedicine)

From Germany - Scientists have identified a genetic mutation strongly associated with type 1 diabetes, according to a report published in Cell Metabolism. Researchers studied a family with a known genetic mutation in the SIRT1 gene--the 'longevity' gene. Four of the family members had type 1 diabetes and all 5 had an autoimmune disorder. Results of gene-sequencing revealed a single mutation in the SIRT1 gene in the family members with diabetes.  When the SIRT1 gene was inactivated in a mouse model, it resulted in the destruction on the insulin-producing regions in the pancreas. These findings provide hope for new treatment options.

 
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