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Gene combinations linked to ALS
Gene combinations linked to ALS (December 24, 2014 - Insidermedicine) From St Louis - A new report published online in the Annals of Neurology, finds that many more cases of ALS may have a genetic origin than previously thought. Researchers examined DNA from over 390 people finding a number new mutations related to amyotrophic lateral sclerosis. Fifteen of the participants had two or more mutations in these genes linked to ALS. Certain single gene mutations have previously been established as causing ALS. But this new research strengthens the notion that having particular combinations of mutations may cause ALS as well. The researchers also found that the onset ALS can happen 10 years earlier in people that have two or more ALS linked gene mutations.